Brain pathology caused in the neonatal macaque by short and prolonged exposures to anticonvulsant drugs

Brain pathology caused in the neonatal macaque by short and prolonged exposures to anticonvulsant drugs

Barbiturates and benzodiazepines are potent GABAA receptor agonists and strong anticonvulsants. In the developing brain they can cause neuronal and oligodendroglia apoptosis, impair synaptogenesis, inhibit neurogenesis and trigger long-term neurocognitive sequelae. In humans, the vulnerable period i...

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Bibliographic Details
Main Authors: Kevin K. Noguchi, Nicole A. Fuhler, Sophie H. Wang, Saverio Capuano, III, Kevin R. Brunner, Shreya Larson, Kristin Crosno, Heather A. Simmons, Andres F. Mejia, Lauren D. Martin, Gregory A. Dissen, Ansgar Brambrink, Chrysanthy Ikonomidou
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Neurobiology of Disease
Subjects:
Antiepileptic
Anticonvulsant
Sedative
Brain injury
Apoptosis
Development
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120305210

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http://www.sciencedirect.com/science/article/pii/S0969996120305210

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