Folate-related gene variants in Irish families affected by neural tube defects

Folate-related gene variants in Irish families affected by neural tube defects

Periconceptional folic acid use can often prevent neural tube defects (NTDs). Variants of genes involved in folate metabolism in mothers and children have been associated with occurrence of NTDs. We identified Irish families with individuals affected by neural tube defects. In these families, we ob...

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Bibliographic Details
Main Authors: Ridgely eFisk Green, Julianne eByrne, Krista S. Crider, Margaret eGallagher, Deborah eKoontz, Robert J. Berry
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Genetics
Subjects:
Neural Tube Defects
folate metabolism
DHFR 19bp deletion
MTHFD1 1958G>A
MTHFR 1298A>C
MTHFR 677C>T
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00223/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00223/full

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