Synthesis, characterization, theoretical studies and biological (antioxidant, anticancer, toxicity and neuroprotective) determinations of a copper(II) complex with 5-hydroxytryptophan

Synthesis, characterization, theoretical studies and biological (antioxidant, anticancer, toxicity and neuroprotective) determinations of a copper(II) complex with 5-hydroxytryptophan

5-Hydroxy-L-tryptophan (5-HTP) is a serotonin pathway metabolite of L-tryptophan in the brain. In the knowledge that the biological properties of some compounds can be modified upon metal complexation, a new solid metal complex, [Cu(5-hydroxytryptophan)2].H2O (Cu5HTP), has been synthesized and chara...

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Bibliographic Details
Main Authors: Juan J. Martínez Medina, Luciana G. Naso, Ana L. Pérez, Alberto Rizzi, Nora B. Okulik, María Valcarcel, Clarisa Salado, Evelina G. Ferrer, Patricia A.M. Williams
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
5-hydroxytryptophan copper(II) complex (Cu5HTP)
Neuroprotective action
Anticancer
Antioxidant
Toxicological assays
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218367192

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http://www.sciencedirect.com/science/article/pii/S0753332218367192

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