p27 Inactivation Provides a Proliferative Advantage to Transplanted Hepatocytes in DPPIV/Rag2 Double Knockout Mice after Repeated Host Liver Injury

Studies were conducted to develop a new DPPIV–/–/Rag2–/– mouse model for hepatocyte transplantation by allogeneic and xenogeneic cells and to compare the proliferative capacity of p27 null hepatocytes versus normal hepatocytes in this system. Dipeptidyl peptidase IV (DPPIV) gene knockout mice, in wh...

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Bibliographic Details
Main Authors: Ray-Hwang Yuan, Atsushi Ogawa, Emi Ogawa, David Neufeld, Liang Zhu, David A. Shafritz
Format: Article
Language:English
Published: SAGE Publishing 2003-11-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/000000003771000147