A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)

A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)

Elucidating signaling pathways that regulate cellular metabolism is essential for a better understanding of normal development and tumorigenesis. Recent studies have shown that mitochondrial pyruvate carrier 1 (MPC1), a crucial player in pyruvate metabolism, is downregulated in colon adenocarcinomas...

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Bibliographic Details
Main Authors: Imelda T Sandoval, Richard Glenn C Delacruz, Braden N Miller, Shauna Hill, Kristofor A Olson, Ana E Gabriel, Kevin Boyd, Christeena Satterfield, Holly Van Remmen, Jared Rutter, David A Jones
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-04-01
Series:eLife
Subjects:
adenomatous polyposis coli
mitochondrial pyruvate carrier
zebrafish
pyruvate metabolism
intestinal differentiation
Online Access:https://elifesciences.org/articles/22706

Internet

https://elifesciences.org/articles/22706

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