A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases

A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases

Bacteria adapt to changing environmental conditions through signal transduction mediated by the two-component system (TCS). Here, the authors combine X-ray crystallography and NMR studies to characterize a pH-gated conformational switch that regulates the phosphatase activity of TCS bifunctional his...

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Bibliographic Details
Main Authors: Yixiang Liu, Joshua Rose, Shaojia Huang, Yangbo Hu, Qiong Wu, Dan Wang, Conggang Li, Maili Liu, Pei Zhou, Ling Jiang
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02310-9

Internet

https://doi.org/10.1038/s41467-017-02310-9

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