Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics

Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics

In calcific aortic valve disease (CAVD), microcalcifications originating from nanoscale calcifying vesicles disrupt the aortic valve (AV) leaflets, which consist of three (biomechanically) distinct layers: the fibrosa, spongiosa, and ventricularis. CAVD has no pharmacotherapy and lacks in vitro mode...

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Bibliographic Details
Main Authors: Dewy C. van der Valk, Casper F. T. van der Ven, Mark C. Blaser, Joshua M. Grolman, Pin-Jou Wu, Owen S. Fenton, Lang H. Lee, Mark W. Tibbitt, Jason L. Andresen, Jennifer R. Wen, Anna H. Ha, Fabrizio Buffolo, Alain van Mil, Carlijn V. C. Bouten, Simon C. Body, David J. Mooney, Joost P. G. Sluijter, Masanori Aikawa, Jesper Hjortnaes, Robert Langer, Elena Aikawa
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Nanomaterials
Subjects:
aortic valve
calcific aortic valve disease
calcification
mechanobiology
bioprinting
3D printing
microdissection
nanoindentation
Online Access:http://www.mdpi.com/2079-4991/8/5/296

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http://www.mdpi.com/2079-4991/8/5/296

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