Effect of metformin treatment on memory and hippocampal neurogenesis decline correlated with oxidative stress induced by methotrexate in rats

Effect of metformin treatment on memory and hippocampal neurogenesis decline correlated with oxidative stress induced by methotrexate in rats

Metformin is currently used as a first-line drug to treat patients with type 2 diabetes. Previous studies have demonstrated that metformin has antioxidant properties and reduces neuroinflammation and hippocampal neuronal cell loss, which eventually improves memory. Methotrexate (MTX) is an antimetab...

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Bibliographic Details
Main Authors: Nataya Sritawan, Kornrawee Suwannakot, Salinee Naewla, Pornthip Chaisawang, Anusara Aranarochana, Apiwat Sirichoat, Wanassanan Pannangrong, Peter Wigmore, Jariya Umka Welbat
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Metformin
Methotrexate
Neurogenesis
Antioxidant
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221010647

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http://www.sciencedirect.com/science/article/pii/S0753332221010647

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