Differences in the composition of the human antibody repertoire by B cell subsets in the blood

Differences in the composition of the human antibody repertoire by B cell subsets in the blood

The vast initial diversity of the antibody repertoire is generated centrally by means of a complex series of V (D) J gene rearrangement events, variation in the site of gene segment joining, and TdT catalyzed N- region addition. Although the diversity is great, close inspection has revealed distinc...

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Bibliographic Details
Main Authors: Eva Szymanska eMroczek, Gregory C Ippolito, Tobias eRogosch, Kam Hon eHoi, Tracy A Hwangpo, Marsha G Brand, Yingxin eZhuang, Cun Ren eLiu, David A Schneider, Michael eZemlin, Elizabeth E Brown, George eGeorgiou, Harry W Schroeder
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Immunology
Subjects:
CDR-H3
human antibody repertoire
B cells subsets
Memory B cell repertoire
heavy chain repertoire
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00096/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00096/full

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