Sex-Differential Impact of Human Cytomegalovirus Infection on <i>In Vitro</i> Reactivity to Toll-Like Receptor 2, 4 and 7/8 Stimulation in Gambian Infants

Sex-Differential Impact of Human Cytomegalovirus Infection on <i>In Vitro</i> Reactivity to Toll-Like Receptor 2, 4 and 7/8 Stimulation in Gambian Infants

Human cytomegalovirus (HCMV) infection rates approach 100% by the first year of life in low-income countries. It is not known if this drives changes to innate immunity in early life and thereby altered immune reactivity to infections and vaccines. Given the panoply of sex differences in immunity, it...

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Bibliographic Details
Main Authors: Momodou Cox, Jane U. Adetifa, Fatou Noho-Konteh, Lady C. Sanyang, Abdoulie Drammeh, Magdalena Plebanski, Hilton C. Whittle, Sarah L. Rowland-Jones, Iain Robertson, Katie L. Flanagan
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Vaccines
Subjects:
human cytomegalovirus
human infants
innate immunity
sex differences
vaccination
toll-like receptor
Online Access:https://www.mdpi.com/2076-393X/8/3/407

Internet

https://www.mdpi.com/2076-393X/8/3/407

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