Islet Autoimmunity in Adults With Impaired Glucose Tolerance and Recently Diagnosed, Treatment Naïve Type 2 Diabetes in the Restoring Insulin SEcretion (RISE) Study

Islet Autoimmunity in Adults With Impaired Glucose Tolerance and Recently Diagnosed, Treatment Naïve Type 2 Diabetes in the Restoring Insulin SEcretion (RISE) Study

The presence of islet autoantibodies and islet reactive T cells (T+) in adults with established type 2 diabetes (T2D) have been shown to identify those patients with more severe β-cell dysfunction. However, at what stage in the progression toward clinical T2D does islet autoimmunity emerge as an imp...

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Main Authors: Barbara M. Brooks-Worrell, Ashley H. Tjaden, Sharon L. Edelstein, Brenda Palomino, Kristina M. Utzschneider, Silva Arslanian, Kieren J. Mather, Thomas A. Buchanan, Kristen J. Nadeau, Karen Atkinson, Elena Barengolts, Steven E. Kahn, Jerry P. Palmer, The RISE Consortium, David A. Ehrmann, Karla A. Temple, Abby Rue, Babak Mokhlesi, Eve Van Cauter, Susan Sam, M. Annette Miller, Karen M. Atkinson, Tsige Gebremedhin, Abigail Kernan-Schloss, Alexandra Kozedub, Brenda K. Montgomery, Emily J. Morse, Tammy Garrett, Tamara S. Hannon, Amale Lteif, Aniket Patel, Robin Chisholm, Karen Moore, Vivian Pirics, Linda Pratt, Susan Gross, Philip S. Zeitler, Jayne Williams, Melanie Cree-Green, Yesenia Garcia Reyes, Krista Vissat, Silva A. Arslanian, Kathleen Brown, Nancy Guerra, Kristin Porter, Sonia Caprio, Mary Savoye, Bridget Pierpont, Anny H. Xiang, Enrique Trigo, Elizabeth Beale, Ting Chow, Fadi N. Hendee, Namir Katkhouda, Krishan Nayak, Mayra Martinez, Cortney Montgomery, Xinhui Wang, Jun Wu, John M. Lachin, Ashley Hogan Tjaden, Mark T. Tripputi, Santica Marcovina, Jessica Harting, John Albers, Dave Hill, Peter J. Savage, Ellen W. Leschek
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
islet reactive T-cells
islet autoantibodies
type 2 diabetes
islet autoimmunity
pre-diabetes
impaired glucose tolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.640251/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.640251/full

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