Loss of Dkk-1 in Osteocytes Mitigates Alveolar Bone Loss in Mice With Periodontitis

Loss of Dkk-1 in Osteocytes Mitigates Alveolar Bone Loss in Mice With Periodontitis

Background: Periodontitis is a highly prevalent infection-triggered inflammatory disease that results in bone loss. Inflammation causes bone resorption by osteoclasts, and also by suppression of bone formation via increase of Dickkopf-1 (Dkk-1), an inhibitor of Wnt signaling. Here, we tested the hyp...

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Bibliographic Details
Main Authors: Paula Goes, Caio Dutra, Lennart Lösser, Lorenz C. Hofbauer, Martina Rauner, Sylvia Thiele
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
periodontitis
Dkk-1
osteocyte
inflammation
bone loss
osteoimmunology
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02924/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02924/full

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