Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma
Abstract Background Lymph node metastasis (LNM) is a major determinant of prognosis and treatment planning of oral squamous cell carcinoma (OSCC). Cysteine cathepsins constitute a family of proteolytic enzymes with known role in the degradation of the extracellular matrix. Involvement in pathologica...
Main Authors: | Frank K. Leusink, Eleftherios Koudounarakis, Michael H. Frank, Ronald Koole, Paul J. van Diest, Stefan M. Willems |
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Format: | Article |
Language: | English |
Published: |
BMC
2018-04-01
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Series: | BMC Cancer |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12885-018-4315-8 |
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