ProteinSeq: high-performance proteomic analyses by proximity ligation and next generation sequencing.

ProteinSeq: high-performance proteomic analyses by proximity ligation and next generation sequencing.

Despite intense interest, methods that provide enhanced sensitivity and specificity in parallel measurements of candidate protein biomarkers in numerous samples have been lacking. We present herein a multiplex proximity ligation assay with readout via realtime PCR or DNA sequencing (ProteinSeq). We...

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Bibliographic Details
Main Authors: Spyros Darmanis, Rachel Yuan Nong, Johan Vänelid, Agneta Siegbahn, Olle Ericsson, Simon Fredriksson, Christofer Bäcklin, Marta Gut, Simon Heath, Ivo Glynne Gut, Lars Wallentin, Mats G Gustafsson, Masood Kamali-Moghaddam, Ulf Landegren
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3183061?pdf=render

Internet

http://europepmc.org/articles/PMC3183061?pdf=render

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