Dying tumor cell-derived exosomal miR-194-5p potentiates survival and repopulation of tumor repopulating cells upon radiotherapy in pancreatic cancer

Dying tumor cell-derived exosomal miR-194-5p potentiates survival and repopulation of tumor repopulating cells upon radiotherapy in pancreatic cancer

Abstract Background Tumor repopulation is a major cause of radiotherapy failure. Previous investigations highlighted that dying tumor cells played vital roles in tumor repopulation through promoting proliferation of the residual tumor repopulating cells (TRCs). However, TRCs also suffer DNA damage a...

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Bibliographic Details
Main Authors: Ming-jie Jiang, Yi-yun Chen, Juan-juan Dai, Dian-na Gu, Zhu Mei, Fu-rao Liu, Qian Huang, Ling Tian
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Molecular Cancer
Subjects:
Tumor repopulation
Tumor repopulating cell
Exosome
microRNA
DNA damage response
Aspirin
Online Access:http://link.springer.com/article/10.1186/s12943-020-01178-6

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http://link.springer.com/article/10.1186/s12943-020-01178-6

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