Suppression of Conditional TDP-43 Transgene Expression Differentially Affects Early Cognitive and Social Phenotypes in TDP-43 Mice

Suppression of Conditional TDP-43 Transgene Expression Differentially Affects Early Cognitive and Social Phenotypes in TDP-43 Mice

Dysregulation of TAR DNA-binding protein 43 (TDP-43) is a hallmark feature of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two fatal neurodegenerative diseases. TDP-43 is a ubiquitously expressed RNA-binding protein with many physiological functions, playing a role in multi...

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Bibliographic Details
Main Authors: Pablo R. Silva, Gabriela V. Nieva, Lionel M. Igaz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Genetics
Subjects:
TDP-43
frontotemporal dementia
amyotrophic lateral sclerosis
transgenic mice
behavior
animal model
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00369/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00369/full

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