The Dual Role of Smad7 in the Control of Cancer Growth and Metastasis

The Dual Role of Smad7 in the Control of Cancer Growth and Metastasis

Smad7 was initially identified as an inhibitor of Transforming growth factor (TGF)-β due mainly to its ability to bind TGF-β receptor type I and prevent TGF-β-associated Smad signaling. More recently, it has been demonstrated that Smad7 can interact with other intracellular proteins and regulate al...

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Bibliographic Details
Main Authors: Carmine Stolfi, Irene Marafini, Veronica De Simone, Francesco Pallone, Giovanni Monteleone
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:International Journal of Molecular Sciences
Subjects:
TGF-β
colorectal cancer
pancreatic cancer
breast cancer
gastric cancer
epithelial-mesenchimal transition
hepatocellular carcinoma
melanoma
genome-wide association study
carcinogenesis
Online Access:http://www.mdpi.com/1422-0067/14/12/23774

Internet

http://www.mdpi.com/1422-0067/14/12/23774

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