Altered neuronal physiology, development, and function associated with a common chromosome 15 duplication involving CHRNA7

Altered neuronal physiology, development, and function associated with a common chromosome 15 duplication involving CHRNA7

Abstract Background Copy number variants (CNVs) linked to genes involved in nervous system development or function are often associated with neuropsychiatric disease. While CNVs involving deletions generally cause severe and highly penetrant patient phenotypes, CNVs leading to duplications tend inst...

Full description

Bibliographic Details
Main Authors: Kesavan Meganathan, Ramachandran Prakasam, Dustin Baldridge, Paul Gontarz, Bo Zhang, Fumihiko Urano, Azad Bonni, Susan E. Maloney, Tychele N. Turner, James E. Huettner, John N. Constantino, Kristen L. Kroll
Format: Article
Language:English
Published: BMC 2021-07-01
Series:BMC Biology
Subjects:
Induced pluripotent stem cells
Cortical neurons
Psychiatric disease
Neurodevelopmental disorders
Copy number variants
Chromosome 15q13.3 duplication
Online Access:https://doi.org/10.1186/s12915-021-01080-7

Internet

https://doi.org/10.1186/s12915-021-01080-7

Similar Items