Bacterial Heat-Stable Enterotoxins: Translation of Pathogenic Peptides into Novel Targeted Diagnostics and Therapeutics

Bacterial Heat-Stable Enterotoxins: Translation of Pathogenic Peptides into Novel Targeted Diagnostics and Therapeutics

Heat-stable toxins (STs) produced by enterotoxigenic bacteria cause endemic and traveler’s diarrhea by binding to and activating the intestinal receptor guanylyl cyclase C (GC-C). Advances in understanding the biology of GC-C have extended ST from a diarrheagenic peptide to a novel therapeutic agent...

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Bibliographic Details
Main Authors: Chang Chang, Brian A. Stoecker, Adam E. Snook, Peng Li, Michael S. Magee, Glen Marszalowicz, Michael Valentino, Jieru E. Lin, Scott A. Waldman
Format: Article
Language:English
Published: MDPI AG 2010-08-01
Series:Toxins
Subjects:
heat-stable enterotoxins (STa)
guanylyl cyclase C
guanylin
uroguanylin
colorectal cancer
hormone insufficiency
hormone replacement therapy
tumor vaccine
irritable bowel syndrome
biomarker
targeted delivery
Online Access:http://www.mdpi.com/2072-6651/2/8/2028/

Internet

http://www.mdpi.com/2072-6651/2/8/2028/

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