Creation of an Anti-Inflammatory, Leptin-Dependent Anti-Obesity Celastrol Mimic with Better Druggability

Creation of an Anti-Inflammatory, Leptin-Dependent Anti-Obesity Celastrol Mimic with Better Druggability

Obesity is characterized by an excessive body mass, but is also closely associated with metabolic syndrome. And, so far, only limited pharmacological treatments are available for obesity management. Celastrol, a pentacyclic triterpenoid from a traditional Chinese medicine (Tripterygium wilfordii Hoo...

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Bibliographic Details
Main Authors: Bo Zhou, Yaxia Yuan, Le Shi, Sheng Hu, Dong Wang, Yang Yang, Yuanhu Pan, Dexin Kong, Alexander N. Shikov, Pierre Duez, Moonsoo Jin, Xiaohua Li, Xuebo Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
natural products
obesity
celastrol
Glycyrrhiza uralensis
glycyrrhetinic acid
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.705252/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.705252/full

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