SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network

SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network

Summary: Dysfunction of the endolysosomal-autophagy network is emerging as an important pathogenic process in Alzheimer’s disease. Mutations in the sorting receptor-encoding gene SORL1 cause autosomal-dominant Alzheimer’s disease, and SORL1 variants increase risk for late-onset AD. To understand the...

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Bibliographic Details
Main Authors: Christy Hung, Eleanor Tuck, Victoria Stubbs, Sven J. van der Lee, Cora Aalfs, Resie van Spaendonk, Philip Scheltens, John Hardy, Henne Holstege, Frederick J. Livesey
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports
Subjects:
endosome
lysosome
autophagy
Alzheimer's disease
amyloid precursor protein
SORL1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721006239

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http://www.sciencedirect.com/science/article/pii/S2211124721006239

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