Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras

Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras

Summary: Growth factor binding to EGFR drives conformational changes that promote homodimerization and transphosphorylation, followed by adaptor recruitment, oligomerization, and signaling through Ras. Whether specific receptor conformations and oligomerization states are necessary for efficient act...

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Bibliographic Details
Main Authors: Samantha I. Liang, Bettina van Lengerich, Kelsie Eichel, Minkwon Cha, David M. Patterson, Tae-Young Yoon, Mark von Zastrow, Natalia Jura, Zev J. Gartner
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718302122

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http://www.sciencedirect.com/science/article/pii/S2211124718302122

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