Frequency of Circulating CD4+Ki67+HLA-DR− T Regulatory Cells Prior to Treatment for Multidrug Resistant Tuberculosis Can Differentiate the Severity of Disease and Predict Time to Culture Conversion

Frequency of Circulating CD4+Ki67+HLA-DR− T Regulatory Cells Prior to Treatment for Multidrug Resistant Tuberculosis Can Differentiate the Severity of Disease and Predict Time to Culture Conversion

Identifying a blood circulating cellular biomarker that can be used to assess severity of disease and predict the time to culture conversion (TCC) in patients with multidrug resistant tuberculosis (MDR-TB) would facilitate monitoring response to treatment and may be of value in the design of future...

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Bibliographic Details
Main Authors: Selena Ferrian, Melinda Ross, Francesca Conradie, Shaheed Vally Omar, Nazir Ismail, Francesca Little, Gilla Kaplan, Dorothy Fallows, Clive M. Gray
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
Treg cells
Mycobacteria tuberculosis
multi-drug resistant tuberculosis
lung cavities
sputum culture
smear grades
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02438/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02438/full

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