Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis

Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis

Drug-induced liver injury (DILI) can broadly be divided into predictable and dose dependent such as acetaminophen (APAP) and unpredictable or idiosyncratic DILI (IDILI). Liver injury from drug hepatotoxicity (whether idiosyncratic or predictable) results in hepatocyte cell death and inflammation. Th...

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Bibliographic Details
Main Authors: Andrea Iorga, Lily Dara, Neil Kaplowitz
Format: Article
Language:English
Published: MDPI AG 2017-05-01
Series:International Journal of Molecular Sciences
Subjects:
hepatotoxicity
human leukocyte antigen (HLA)
adaptation
acetaminophen
DILI
apoptosis
necrosis
Online Access:http://www.mdpi.com/1422-0067/18/5/1018

Internet

http://www.mdpi.com/1422-0067/18/5/1018

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