Dystrophin Deficiency Leads to Genomic Instability in Human Pluripotent Stem Cells via NO Synthase-Induced Oxidative Stress

Dystrophin Deficiency Leads to Genomic Instability in Human Pluripotent Stem Cells via NO Synthase-Induced Oxidative Stress

Recent data on Duchenne muscular dystrophy (DMD) show myocyte progenitor’s involvement in the disease pathology often leading to the DMD patient’s death. The molecular mechanism underlying stem cell impairment in DMD has not been described. We created dystrophin-deficient human pluripotent stem cell...

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Bibliographic Details
Main Authors: Sarka Jelinkova, Petr Fojtik, Aneta Kohutova, Aleksandra Vilotic, Lenka Marková, Martin Pesl, Tereza Jurakova, Miriama Kruta, Jan Vrbsky, Renata Gaillyova, Iveta Valášková, Ivan Frák, Alain Lacampagne, Giancarlo Forte, Petr Dvorak, Albano C. Meli, Vladimir Rotrekl
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cells
Subjects:
DMD
dystrophin
pluripotent stem cells
genome stability
ROS
NO synthases
Online Access:http://www.mdpi.com/2073-4409/8/1/53

Internet

http://www.mdpi.com/2073-4409/8/1/53

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