Circulating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer

Circulating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer

Following on reports that miR-424 expression promotes oncogenesis, Domenico Albino et al. find that extracellular vesicles (EVs) in the plasma of prostate cancer patients secrete miR-424. Using cell-based and animal models, they demonstrate that EV-mediated release of miR-424 can transfer oncogenic...

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Bibliographic Details
Main Authors: Domenico Albino, Martina Falcione, Valeria Uboldi, Dada Oluwaseyi Temilola, Giada Sandrini, Jessica Merulla, Gianluca Civenni, Aleksandra Kokanovic, Alessandra Stürchler, Dheeraj Shinde, Mariangela Garofalo, Ricardo Pereira Mestre, Vera Constâncio, Martha Wium, Jacopo Burrello, Nicolò Baranzini, Annalisa Grimaldi, Jean-Philippe Theurillat, Daniela Bossi, Lucio Barile, Rui M. Henrique, Carmen Jeronimo, Luiz Fernando Zerbini, Carlo V. Catapano, Giuseppina M. Carbone
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-020-01642-5

Internet

https://doi.org/10.1038/s42003-020-01642-5

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