Neonatal T Helper 17 Responses Are Skewed Towards an Immunoregulatory Interleukin-22 Phenotype

Neonatal T Helper 17 Responses Are Skewed Towards an Immunoregulatory Interleukin-22 Phenotype

Newborns are frequently affected by mucocutaneous candidiasis. Th17 cells essentially limit mucosal invasion by commensal Candida spp. Here, we sought to understand the molecular basis for the developmental lack of Th17 cell responses in circulating blood neonatal T cells. Naive cord blood CD4 T cel...

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Bibliographic Details
Main Authors: Hamid R. Razzaghian, Zohreh Sharafian, Ashish A. Sharma, Guilaine K. Boyce, Kelsey Lee, Rachel Da Silva, Paul C. Orban, Rafick-Pierre Sekaly, Colin J. Ross, Pascal M. Lavoie
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
Stat3
gene regulation
T helper (Th) 17 cells
TGF-β signaling
neonatal
T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.655027/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.655027/full

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