Nicotine Alters Estrogen Receptor-Beta-Regulated Inflammasome Activity and Exacerbates Ischemic Brain Damage in Female Rats

Nicotine Alters Estrogen Receptor-Beta-Regulated Inflammasome Activity and Exacerbates Ischemic Brain Damage in Female Rats

Smoking is a preventable risk factor for stroke and smoking-derived nicotine exacerbates post-ischemic damage via inhibition of estrogen receptor beta (ER-β) signaling in the brain of female rats. ER-β regulates inflammasome activation in the brain. Therefore, we hypothesized that...

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Bibliographic Details
Main Authors: Nathan D. d’Adesky, Juan Pablo de Rivero Vaccari, Pallab Bhattacharya, Marc Schatz, Miguel A. Perez-Pinzon, Helen M. Bramlett, Ami P. Raval
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:International Journal of Molecular Sciences
Subjects:
stroke
inflammasome
nicotine
estrogen
smoking
women’s health
Online Access:http://www.mdpi.com/1422-0067/19/5/1330

Internet

http://www.mdpi.com/1422-0067/19/5/1330

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