Calibration transfer for bioprocess Raman monitoring using Kennard Stone piecewise direct standardization and multivariate algorithms

Calibration transfer for bioprocess Raman monitoring using Kennard Stone piecewise direct standardization and multivariate algorithms

Abstract In the biopharmaceutical industry, Raman spectroscopy is now a proven PAT tool that enables in‐line simultaneous monitoring of several CPPs and CQAs in real‐time. However, as Raman monitoring requires multivariate modeling, variabilities unknown by models can impact the monitoring predictio...

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Bibliographic Details
Main Authors: Laure Pétillot, Fiona Pewny, Martin Wolf, Célia Sanchez, Fabrice Thomas, Johan Sarrazin, Katharina Fauland, Hermann Katinger, Charlotte Javalet, Christophe Bonneville
Format: Article
Language:English
Published: Wiley 2020-11-01
Series:Engineering Reports
Subjects:
cell culture monitoring
model transferability
multivariate model maintenance
process analytical technology
Raman spectroscopy
Online Access:https://doi.org/10.1002/eng2.12230

Internet

https://doi.org/10.1002/eng2.12230

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