The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

Neuronal function is highly sensitive to changes in oxygen levels, but how hypoxia affects dendritic spine formation and synaptogenesis is unknown. Here we report that hypoxia, chemical inhibition of the oxygen-sensing prolyl hydroxylase domain proteins (PHDs), and silencing of Phd2 induce immature...

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Bibliographic Details
Main Authors: Inmaculada Segura, Christian Lange, Ellen Knevels, Anastasiya Moskalyuk, Rocco Pulizzi, Guy Eelen, Thibault Chaze, Cicerone Tudor, Cyril Boulegue, Matthew Holt, Dirk Daelemans, Mariette Matondo, Bart Ghesquière, Michele Giugliano, Carmen Ruiz de Almodovar, Mieke Dewerchin, Peter Carmeliet
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716301681

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http://www.sciencedirect.com/science/article/pii/S2211124716301681

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