Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis.

Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis.

Non-Alcoholic Fatty Liver Disease (NAFLD) is a major form of chronic liver disease in the general population in relation to its high prevalence among overweight/obese individuals and patients with diabetes type II or metabolic syndrome. NAFLD can progress to steatohepatitis (NASH), fibrosis and cirr...

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Main Authors: Stefania Cannito, Elisabetta Morello, Claudia Bocca, Beatrice Foglia, Elisa Benetti, Erica Novo, Fausto Chiazza, Mara Rogazzo, Roberto Fantozzi, Davide Povero, Salvatore Sutti, Elisabetta Bugianesi, Ariel E Feldstein, Emanuele Albano, Massimo Collino, Maurizio Parola
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5331985?pdf=render

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http://europepmc.org/articles/PMC5331985?pdf=render

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