Endoplasmic reticulum (ER) stress inducible factor cysteine-rich with EGF-like domains 2 (Creld2) is an important mediator of BMP9-regulated osteogenic differentiation of mesenchymal stem cells.

Endoplasmic reticulum (ER) stress inducible factor cysteine-rich with EGF-like domains 2 (Creld2) is an important mediator of BMP9-regulated osteogenic differentiation of mesenchymal stem cells.

Mesenchymal stem cells (MSCs) are multipotent progenitors that can undergo osteogenic differentiation under proper stimuli. We demonstrated that BMP9 is one of the most osteogenic BMPs. However, the molecular mechanism underlying BMP9-initiated osteogenic signaling in MSCs remains unclear. Through g...

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Bibliographic Details
Main Authors: Jiye Zhang, Yaguang Weng, Xing Liu, Jinhua Wang, Wenwen Zhang, Stephanie H Kim, Hongyu Zhang, Ruidong Li, Yuhan Kong, Xiang Chen, Wei Shui, Ning Wang, Chen Zhao, Ningning Wu, Yunfeng He, Guoxin Nan, Xian Chen, Sheng Wen, Hongmei Zhang, Fang Deng, Lihua Wan, Hue H Luu, Rex C Haydon, Lewis L Shi, Tong-Chuan He, Qiong Shi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3760886?pdf=render

Internet

http://europepmc.org/articles/PMC3760886?pdf=render

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