The FMS like Tyrosine Kinase 3 (FLT3) Is Overexpressed in a Subgroup of Multiple Myeloma Patients with Inferior Prognosis

The FMS like Tyrosine Kinase 3 (FLT3) Is Overexpressed in a Subgroup of Multiple Myeloma Patients with Inferior Prognosis

Therapy resistance remains a major challenge in the management of multiple myeloma (MM). We evaluated the expression of FLT3 tyrosine kinase receptor (FLT3, CD135) in myeloma cells as a possible clonal driver. FLT3 expression was analyzed in bone marrow biopsies of patients with monoclonal gammopath...

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Bibliographic Details
Main Authors: Normann Steiner, Karin Jöhrer, Selina Plewan, Andrea Brunner-Véber, Georg Göbel, David Nachbaur, Dominik Wolf, Eberhard Gunsilius, Gerold Untergasser
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
multiple myeloma
<i>FLT3</i>
midostaurin
gilteritinib
overexpression
Online Access:https://www.mdpi.com/2072-6694/12/9/2341

Internet

https://www.mdpi.com/2072-6694/12/9/2341

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