Design of a Gene Panel to Expose the Versatile Role of Hepatic Stellate Cells in Human Liver Fibrosis

Design of a Gene Panel to Expose the Versatile Role of Hepatic Stellate Cells in Human Liver Fibrosis

The pivotal cell involved in the pathogenesis of liver fibrosis, i.e., the activated hepatic stellate cell (HSC), has a wide range of activities during the initiation, progression and even regression of the disease. These HSC-related activities encompass cellular activation, matrix synthesis and deg...

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Bibliographic Details
Main Authors: Fransien van Dijk, Christa M. Hazelhoff, Eduard Post, Gerian G. H. Prins, Krista Rombouts, Klaas Poelstra, Peter Olinga, Leonie Beljaars
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Pharmaceutics
Subjects:
drug development
primary hepatic stellate cells
precision-cut liver slices
myofibroblast
reversion
fibrosis gene panel
transforming growth factor β
platelet-derived growth factor bb
Online Access:https://www.mdpi.com/1999-4923/12/3/278

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https://www.mdpi.com/1999-4923/12/3/278

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