NFAT5 mediates hypertonic stress-induced atherosclerosis via activating NLRP3 inflammasome in endothelium

NFAT5 mediates hypertonic stress-induced atherosclerosis via activating NLRP3 inflammasome in endothelium

Abstract Background How high-salt intake leads to the occurrence of many cardiovascular diseases such as atherosclerosis is a fundamental question in pathology. Here we postulated that high-salt-induced NFAT5 controls the inflammasome activation by directly regulating NLRP3, which mediates the expre...

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Bibliographic Details
Main Authors: Pingping Ma, Shenfang Zha, Xinkun Shen, Yulan Zhao, Li Li, Li Yang, Mingxing Lei, Wanqian Liu
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Cell Communication and Signaling
Subjects:
Atherosclerosis
NLRP3 inflammasome
NFAT5
Hypertonic stress
Endothelium
Online Access:http://link.springer.com/article/10.1186/s12964-019-0406-7

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http://link.springer.com/article/10.1186/s12964-019-0406-7

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