CORNAS: coverage-dependent RNA-Seq analysis of gene expression data without biological replicates

CORNAS: coverage-dependent RNA-Seq analysis of gene expression data without biological replicates

Abstract Background In current statistical methods for calling differentially expressed genes in RNA-Seq experiments, the assumption is that an adjusted observed gene count represents an unknown true gene count. This adjustment usually consists of a normalization step to account for heterogeneous sa...

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Bibliographic Details
Main Authors: Joel Z. B. Low, Tsung Fei Khang, Martti T. Tammi
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Bioinformatics
Subjects:
RNA-Seq
Unreplicated experiments
Bayesian statistics
Differential gene expression
Sequencing coverage
Illumina
Online Access:http://link.springer.com/article/10.1186/s12859-017-1974-4

Internet

http://link.springer.com/article/10.1186/s12859-017-1974-4

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