Saturation transfer MRI is sensitive to neurochemical changes in the rat brain due to chronic unpredictable mild stress

Abstract Chemical exchange saturation transfer (CEST) MRI was performed for the evaluation of cerebral metabolic changes in a rat model of depressive-like disease induced by chronic unpredictable mild stress (CUMS). CEST Z-spectra were acquired on a 7 T MRI with two saturation B1 amplitudes (0.5 and...

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Bibliographic Details
Main Authors: Anna Pankowska, Agata Chudzik, Tymoteusz Słowik, Artur Łazorczyk, Katarzyna Kochalska, Marta Andres-Mach, Wilfred W. Lam, Radosław Pietura, Radosław Rola, Greg J. Stanisz, Anna Orzyłowska
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97991-0