Histocompatibility Complex Status and Mendelian Randomization Analysis in Unsolved Antibody Deficiency

Histocompatibility Complex Status and Mendelian Randomization Analysis in Unsolved Antibody Deficiency

The pathogenesis in the majority of patients with common variable immunodeficiency (CVID), the most common symptomatic primary immunodeficiency, remains unknown. We aimed to compare the minor and major histocompatibility complex (MHC) markers as well as polygenic scores of common genetic variants be...

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Bibliographic Details
Main Authors: Hassan Abolhassani, Che Kang Lim, Asghar Aghamohammadi, Lennart Hammarström
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
primary immunodeficiency
antibody deficiency
common variable immunodeficiency (CVID)
whole exome sequencing
full-resolution MHC typing
Mendelian randomization
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00014/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00014/full

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