Holotoxin A1 Induces Apoptosis by Activating Acid Sphingomyelinase and Neutral Sphingomyelinase in K562 and Human Primary Leukemia Cells

Holotoxin A1 Induces Apoptosis by Activating Acid Sphingomyelinase and Neutral Sphingomyelinase in K562 and Human Primary Leukemia Cells

Marine triterpene glycosides are attractive candidates for the development of anticancer agents. Holotoxin A1 is a triterpene glycoside found in the edible sea cucumber, Apostichopus (Stichopus) japonicus. We previously showed that cladoloside C2, the 25(26)-dihydro derivative of holotoxin A1, induc...

Full description

Bibliographic Details
Main Authors: Seong-Hoon Yun, Eun-Hye Sim, Sang-Heum Han, Jin-Yeong Han, Sung-Hyun Kim, Alexandra S. Silchenko, Valentin A. Stonik, Joo-In Park
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Marine Drugs
Subjects:
marine triterpene glycoside
acid sphingomyelinase
neutral sphingomyelinase
apoptosis
leukemia
Online Access:http://www.mdpi.com/1660-3397/16/4/123

Internet

http://www.mdpi.com/1660-3397/16/4/123

Similar Items