Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM

Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM

Abstract Background Tumour cells have a high demand for arginine. However, a subset of glioblastomas has a defect in the arginine biosynthetic pathway due to epigenetic silencing of the rate limiting enzyme argininosuccinate synthetase (ASS1). These tumours are auxotrophic for arginine and susceptib...

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Bibliographic Details
Main Authors: Lina Mörén, Richard Perryman, Tim Crook, Julia K. Langer, Kevin Oneill, Nelofer Syed, Henrik Antti
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Cancer
Subjects:
Glioblastoma
Epigenetics
ASS1
Arginine
ADI-PEG20
Metabolomics
Online Access:http://link.springer.com/article/10.1186/s12885-018-4040-3

Internet

http://link.springer.com/article/10.1186/s12885-018-4040-3

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