DOK7 Gene Therapy Enhances Neuromuscular Junction Innervation and Motor Function in Aged Mice

DOK7 Gene Therapy Enhances Neuromuscular Junction Innervation and Motor Function in Aged Mice

Summary: Muscle denervation at the neuromuscular junction (NMJ), the essential synapse between motor neuron and skeletal muscle, is associated with age-related motor impairment. Therefore, improving muscle innervation at aged NMJs may be an effective therapeutic strategy for treating the impairment....

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Bibliographic Details
Main Authors: Ryo Ueta, Satoshi Sugita, Yoshihiko Minegishi, Akira Shimotoyodome, Noriyasu Ota, Noboru Ogiso, Takahiro Eguchi, Yuji Yamanashi
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:iScience
Subjects:
Clinical Genetics
Molecular Mechanism of Gene Regulation
Musculoskeletal Medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220305733

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http://www.sciencedirect.com/science/article/pii/S2589004220305733

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