Luteolin Modulates SERCA2a Leading to Attenuation of Myocardial Ischemia/ Reperfusion Injury via Sumoylation at Lysine 585 in Mice

Luteolin Modulates SERCA2a Leading to Attenuation of Myocardial Ischemia/ Reperfusion Injury via Sumoylation at Lysine 585 in Mice

Background/Aims: The myocardial sarcoplasmic reticulum calcium ATPase (SERCA2a) is a pivotal pump responsible for calcium cycling in cardiomyocytes. The present study investigated the effect of luteolin (Lut) on restoring SERCA2a protein level and stability reduced by myocardial ischemia/reperfusion...

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Bibliographic Details
Main Authors: Yinping Du, Ping Liu, Tongda Xu, Defeng Pan, Hong Zhu, Nana Zhai, Yanbin Zhang, Dongye Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
Serca2a
Ischemia/reperfusion
SUMOylation
Luteolin
Online Access:https://www.karger.com/Article/FullText/487283

Internet

https://www.karger.com/Article/FullText/487283

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