CD44 Loss Disrupts Lung Lipid Surfactant Homeostasis and Exacerbates Oxidized Lipid-Induced Lung Inflammation

CD44 Loss Disrupts Lung Lipid Surfactant Homeostasis and Exacerbates Oxidized Lipid-Induced Lung Inflammation

Alveolar macrophages (AMs) are CD44 expressing cells that reside in the alveolar space where they maintain lung homeostasis by serving critical roles in immunosurveillance and lipid surfactant catabolism. AMs lacking CD44 are unable to bind the glycosaminoglycan, hyaluronan, which compromises their...

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Bibliographic Details
Main Authors: Yifei Dong, Arif A. Arif, Jian Guo, Zongyi Ha, Sally S. M. Lee-Sayer, Grace F. T. Poon, Manisha Dosanjh, Calvin D. Roskelley, Tao Huan, Pauline Johnson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
CD44
alveolar macrophage
lung surfactant lipids
oxidized lipids
lipidomics
flow cytometry
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00029/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00029/full

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