Breast cancer bone metastases are attenuated in a Tgif1-deficient bone microenvironment

Breast cancer bone metastases are attenuated in a Tgif1-deficient bone microenvironment

Abstract Background Osteoclast activation is a hallmark of breast cancer-induced bone disease while little is known about the role of osteoblasts in this process. Recently, we identified the homeodomain protein TG-interacting factor-1 (Tgif1) as a crucial regulator of osteoblast function. In this st...

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Bibliographic Details
Main Authors: Marie-Therese Haider, Hiroaki Saito, Jennifer Zarrer, Kevin Uzhunnumpuram, Sankari Nagarajan, Vijayalakshmi Kari, Michael Horn-Glander, Stefan Werner, Eric Hesse, Hanna Taipaleenmäki
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Bone metastases
Osteoblasts
Tgif1
Online Access:http://link.springer.com/article/10.1186/s13058-020-01269-8

Internet

http://link.springer.com/article/10.1186/s13058-020-01269-8

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