Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons

Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons

Niemann-Pick type C (NPC) is a neurodegenerative disease characterized by the intralysosomal accumulation of cholesterol leading to neuronal apoptosis. We have previously reported the activation of the c-Abl/p73 proapoptotic pathway in the cerebellum of NPC mice; however, upstream signals underlying...

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Bibliographic Details
Main Authors: Andres Klein, Carola Maldonado, Lina M. Vargas, Marcela Gonzalez, Fermín Robledo, Karen Perez de Arce, Francisco J. Muñoz, Claudio Hetz, Alejandra R. Alvarez, Silvana Zanlungo
Format: Article
Language:English
Published: Elsevier 2011-01-01
Series:Neurobiology of Disease
Subjects:
Niemann-Pick type C
c-Abl/p73
Oxidative stress
Apoptosis
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110003098

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http://www.sciencedirect.com/science/article/pii/S0969996110003098

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