HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+ T Cells

HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+ T Cells

Several pattern-recognition receptors sense HIV-1 replication products and induce type I interferon (IFN-I) production under specific experimental conditions. However, it is thought that viral sensing and IFN induction are virtually absent in the main target cells of HIV-1 in vivo. Here, we show tha...

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Bibliographic Details
Main Authors: Jolien Vermeire, Ferdinand Roesch, Daniel Sauter, Réjane Rua, Dominik Hotter, Anouk Van Nuffel, Hanne Vanderstraeten, Evelien Naessens, Veronica Iannucci, Alessia Landi, Wojciech Witkowski, Ann Baeyens, Frank Kirchhoff, Bruno Verhasselt
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
HIV
Vpr
Vpu
interferon
cGAS
T cells
dendritic cells
innate sensing
NF-κB
CD4
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716312451

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http://www.sciencedirect.com/science/article/pii/S2211124716312451

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