The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome

The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome

Abstract Background Peutz-Jeghers syndrome (PJS) is caused by mutations in serine/threonine kinase 11 (STK11) gene. The increased cancer risk has been connected to P53 pathway. Methods PJS probands with STK11 mutation were included in the function analysis. P53 activity elevated by STK11 mutants was...

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Bibliographic Details
Main Authors: Yu-Liang Jiang, Zi-Ye Zhao, Bai-Rong Li, Fu Yang, Jing Li, Xiao-Wei Jin, Hao Wang, En-Da Yu, Shu-Han Sun, Shou-Bin Ning
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Medical Genetics
Subjects:
Peutz-Jeghers syndrome (PJS)
STK11 gene
P53 gene
Cancer risk
Reporter gene technique
Online Access:http://link.springer.com/article/10.1186/s12881-018-0626-5

Internet

http://link.springer.com/article/10.1186/s12881-018-0626-5

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