An Immunomodulatory Gallotanin-Rich Fraction From Caesalpinia spinosa Enhances the Therapeutic Effect of Anti-PD-L1 in Melanoma

An Immunomodulatory Gallotanin-Rich Fraction From Caesalpinia spinosa Enhances the Therapeutic Effect of Anti-PD-L1 in Melanoma

PD-1/PD-L1 pathway plays a role in inhibiting immune response. Therapeutic antibodies aimed at blocking the PD-1/PD-L1 interaction have entered clinical development and have been approved for a variety of cancers. However, the clinical benefits are reduced to a group of patients. The research in com...

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Bibliographic Details
Main Authors: Paola Lasso, Alejandra Gomez-Cadena, Claudia Urueña, Alena Donda, Amaia Martinez-Usatorre, Pedro Romero, Alfonso Barreto, Susana Fiorentino
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
breast cancer
combined therapy
immunotherapy
natural products
melanoma
P2Et extract
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.584959/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.584959/full

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