Biophysically inspired rational design of structured chimeric substrates for DNAzyme cascade engineering.

The development of large-scale molecular computational networks is a promising approach to implementing logical decision making at the nanoscale, analogous to cellular signaling and regulatory cascades. DNA strands with catalytic activity (DNAzymes) are one means of systematically constructing molec...

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Bibliographic Details
Main Authors: Matthew R Lakin, Carl W Brown, Eli K Horwitz, M Leigh Fanning, Hannah E West, Darko Stefanovic, Steven W Graves
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4210168?pdf=render