Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.

Histone methylation is dynamically regulated to shape the epigenome and adjust central nuclear processes including transcription, cell cycle control and DNA repair. Lysine-specific histone demethylase 2 (LSD2) has been implicated in multiple types of human cancers. However, its functions remain poor...

Full description

Bibliographic Details
Main Authors: Xiaojuan Zhang, Sisi Tian, Sara E Beese-Sims, Jingjie Chen, Nara Shin, Monica P Colaiácovo, Hyun-Min Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-07-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009715